Boosting myocardial repair

Enhanced Myocardial Repair with CardioChimeras

Dual stem cell transplantation of c-kit positive cardiac progenitor cells (CPCs) and mesen-chymal stem cells (MSCs) after infarction support modest improvements in cardiac function, however there are currently no reports substantiating a single stem cell type supporting both direct and indirect mechanisms of myocardial repair. Therefore we created a CardioChimera, a stem/progenitor cell formed ...

Stem cells for myocardial repair

The adult human heart has limited regenerative capacity and therefore any significant myocardial damage results in progressive deterioration in its function. Cell-based cardiac repair represents an exciting approach for rebuilding the injured heart. Consequentially, during the last decade, significant efforts have been made to assess the potential role of skeletal myoblasts, foetal cardiomyocyt...

Myocardial repair around-the-clock.

Stem cells for myocardial repair.

There is a growing interest in the clinical application for stem cell as a novel therapy for treatment of acute myocardial infarction and chronic myocardial ischaemia. The initial premise is the transplanted exogenous stem cells can engraft and integrate with host myocardium for cardiac regeneration. However, recent experimental studies suggest that multiple mechanisms, including remodelling of...

Myocardial Self-Repair and Congenital Heart Disease